Chemical Structure : UR241-2
CAS No.:
2758288-13-8
UR241-2
(UR 241-2)
Catalog No.: PC-26786Not For Human Use, Lab Use Only.
UR241-2 is a potent and selective IRAK4 inhibitor with IC50 of 1.93 nM in HotSpot Kinase assays, inhibits NF-κβ nuclear translocation and blocks IL-1β–induced IRAK4 phosphorylation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UR241-2 is a potent and selective IRAK4 inhibitor with IC50 of 1.93 nM in HotSpot Kinase assays, inhibits NF-κβ nuclear translocation and blocks IL-1β–induced IRAK4 phosphorylation.
UR241-2 (5 and 15 nM, 4 h) suppresses IRAK4 phosphorylation induced by hIL-1β (10 ng, 45 min) in human HCH-1 EOC cells.
UR241-2 suppresses NF-κβ activation downstream of IL-1/TLR signaling.
UR241-2 UR241-2 (20-60 uM, 48 h) resulted in a dose-dependent reduction in viability across ES2, HCH1, SKOV-3, OVCAR-3, and OVCAR-8 cell lines.
UR241-2 at 20 mg/kg (intraperitoneal, once daily) suppressed tumor growth in SKOV-3 xenograft model without overt toxicity.
UR241-2 decreases tumor burden at the needle injury site and increases the number of MHCII expressing myeloid cells in the peritoneal cavity and tumor.
UR241-2 alters ECM and neutrophil-related gene expression in tumors.
Physicochemical Properties
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M.Wt
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427.48
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Formula
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C20H21N5O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(1,1-dioxidothiomorpholino)-2-methoxyphenyl)-6-(1H-pyrazol-3-yl)picolinamide
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References
1. Ho TC, et al. bioRxiv [Preprint]. 2024 Nov 11:2024.11.09.622796.
2. Ho TC, et al. Leukemia. 2026 Feb;40(2):293-303.
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