Chemical Structure : USP24-i-101
CAS No.:
2758815-50-6
USP24-i-101
(Compound 677-8)
Catalog No.: PC-24713Not For Human Use, Lab Use Only.
USP24-i-101 (Compound 677-8) is a specific small molecule inhibitor of USP24, induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
USP24-i-101 (Compound 677-8) is a specific small molecule inhibitor of USP24, induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively.
USP24-i-101 can dramatically induce autophagy through upregulation of ULK1, LC3 and ULK phosphorylation at Ser555 in lung cancer to negatively regulate drug resistance.
USP24-i-101 is better than USP24-i (NCI677397) in the inhibition of drug resistance in Taxol-induced drug resistant A549 cells (A549-T24).
USP24-i-101 inhibits drug resistance in EGFRL858R lung cancer drug resistant mice.
USP24-i-101 inhibits the expression of ABCG2 and PD-L1 and maintaining genomic integrity, resulting in the inhibition of drug resistance acquired by gefitinib- or Taxol-treatment of lung cancer.
Physicochemical Properties
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M.Wt
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429.58
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Formula
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C26H27N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(10-(2-(4-methylpiperazin-1-yl)ethyl)-10H-phenothiazin-2-yl)(phenyl)methanone
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References
1. Young MJ, et al. Cell Death Differ. 2024 May;31(5):574-591.
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