USP5-IN-2

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Chemical Structure : USP5-IN-2

Catalog No.: PC-28630Not For Human Use, Lab Use Only.

USP5-IN-2 (Compound 25) is a highly selective small molecule inhibitor of deubiquitinating enzyme USP5 with IC50 of 39.15 uM, does not inhibit USP18 or any other detected deISGylases, reduces SARS-CoV-2 replication, also shows antiviral activity against influenza A virus and encephalomyocarditis virus with IC50 of ~1.9 µM and ~5.1 µM, respectively

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	431.96
Formula	C19H34ClN5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((S)-2-acetamido-4-methylpentanamido)-6-amino-N-(2-oxo-2-(prop-2-yn-1-ylamino)ethyl)hexanamide hydrochloride

References

1. Jones HBL, et al. NPJ Drug Discov. 2026 Oct 26;3(1):52.

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USP5-IN-2

Biological Activity

Physicochemical Properties

References

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