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Chemical Structure : USP8-IN-22c
CAS No.: 924296-17-3
Catalog No.: PC-45857Not For Human Use, Lab Use Only.
USP8-IN-22c is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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USP8-IN-22c is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM.
USP8-IN-22c shows no inhibitory activity for USP7, USP5, SENP1, Uch-L3, and caspase 3 (IC50>100 uM), and displays partial activity against Uch-L3.
USP8-IN-22c inhibits the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50 values in the 0.5-1.5 uM range.
| M.Wt | 287.2756 | |
| Formula | C16H9N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 20.1 mg/mL |
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| Chemical Name/SMILES |
9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-[(2-propen-1-yloxy)imino]- |
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1. Colombo M, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.
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