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Chemical Structure : USP8 inhibitor RA-9
Catalog No.: PC-72534Not For Human Use, Lab Use Only.
USP8 inhibitor RA-9 is a small molecule USP8 inhibitor.
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USP8 inhibitor RA-9 is a small molecule USP8 inhibitor.
USP8 inhibitor RA-9 inhibits colony formation of breast, ovarian and cervical cancer cells with IC50 of <100 nM, completely abrogating colony formation at 0.3 uM.
USP8 inhibitor RA-9 inhibits deubiqutinating enzymes (DUB) and alters expression of DUB-regulated oncogenes and tumor suppressors.
USP8 inhibitor RA-9 directly suppress activities of major cellular DUB, such as UCH-L1, UCH-L3, USP2, USP5 and USP8, but do not inhibit Ataxin-3, A20CD, BAP1, Otubain 1, USP7/HAUSP or USP14.
| M.Wt | 365.34 | |
| Formula | C19H15N3O5 | |
| Appearance | Solid | |
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1. Issaenko OA, et al. Cell Cycle. 2012 May 1;11(9):1804-17.
2. Treppiedi D, et al. Endocr Relat Cancer. 2021 Jun 28;28(8):573-582
3. Zhu Y, et al. Aging (Albany NY). 2021 Jun 3;13(11):14999-15012.
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