Chemical Structure : USP8 inhibitor W-17
CAS No.:
USP8 inhibitor W-17
Catalog No.: PC-27996Not For Human Use, Lab Use Only.
USP8 inhibitor W-17 is a potent, selective USP8 inhibitor with IC50 of 108 nM, exhibits no activity against USP7, USP10, and USP14 (IC50>10 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
USP8 inhibitor W-17 is a potent, selective USP8 inhibitor with IC50 of 108 nM, exhibits no activity against USP7, USP10, and USP14 (IC50>10 uM).
W-17 can stabilize USP8 in HCT116 and SW480 cells.
W-17 exhibits minimal inhibitory effects on USP family deubiquitinases, including USP7, USP10, and USP14.
W-17 directly engages USP8 in cells and accelerates PD-L1 proteasomal degradation via enhanced K48-linked polyubiquitination.
W-17 can promote the destabilization of PD-L1 and enhance T-cell mediated tumor cell killing activity.
W-17 (10-20 mg/kg/day) suppresses tumor growth and promotes immune activation in immunocompetent CT26 colorectal cancer model.
Physicochemical Properties
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M.Wt
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308.36
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Formula
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C13H16N4O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1,1-dioxidothiomorpholino)(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol-2-yl)methanone
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References
1. Zhiyu Song, et al. Transl Oncol. 2026 Aug 5:72:102956.
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