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Chemical Structure : UbV SP.1
Catalog No.: PC-72760Not For Human Use, Lab Use Only.
UbV SP.1 is potent, selective inhibitor of STAMBP isopeptidase activity with KD of 0.05/0.18 uM for STAMBP/STAMBPL1, respectively.
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UbV SP.1 is potent, selective inhibitor of STAMBP isopeptidase activity with KD of 0.05/0.18 uM for STAMBP/STAMBPL1, respectively.
UbV SP.1 showed no binding to two USP-family DUBs (USP7 and USP14), a JAMM-family DUB complex BRISC, or an OTU-family DUB OTUD1.
STAMBP is a member of the JAB1/MPN/MOV34 (JAMM) metalloprotease family of DUB enzymes.
UbV SP.1 binds both the full-length and the JAMM domain of STAMBP (STAMBPJAMM), far exceeding the reported small-molecule inhibitor BC-1471.
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