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Chemical Structure : UbcH5c-IN-6d
Catalog No.: PC-60354Not For Human Use, Lab Use Only.
UbcH5c-IN-6d is a potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM.
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UbcH5c-IN-6d is a potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM.
UbcH5c-IN-6d suppresses the activation of the NF-κB signaling pathway by selectively covalently binding to the Cys85 residue of UbcH5c.
UbcH5c-IN-6d exhibits potent anti-inflammatory activity against complete Freund’s adjuvant-induced adjuvant arthritis in vivo.
| M.Wt | 413.31 | |
| Formula | C22H21BrO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen H, et al. J Med Chem. 2017 Aug 24;60(16):6828-6852.
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