Chemical Structure : Ubistatin A
CAS No.:
1052534-76-5
Ubistatin A
Catalog No.: PC-27977Not For Human Use, Lab Use Only.
Ubistatin A (ubiA, Ubistatin-A) is a small molecule inhibitor of proteasome-dependent degradation by binding the ubiquitin chain, binds ubiquitin and diubiquitin, shows strong preference for K48-linkages over K11 and K63, can penetrate cancer cells and alters cellular ubiquitin landscape.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ubistatin A (ubiA, Ubistatin-A) is a small molecule inhibitor of proteasome-dependent degradation by binding the ubiquitin chain, binds ubiquitin and diubiquitin, shows strong preference for K48-linkages over K11 and K63, can penetrate cancer cells and alters cellular ubiquitin landscape.
Ubistatin A blockscell cycle progression by inhibiting cyclin B proteolysis and inhibits degradation of ubiquitinated Sic1 by purified proteasomes.
Ubistatin A shields ubiquitin conjugates from disassembly by a range of deubiquitinases and by the 26S proteasome.
Ubistatin A acts by disrupting a critical protein-protein interaction in the ubiquitin-proteasome system.
Physicochemical Properties
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M.Wt
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960.75
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Formula
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C34H20N4Na4O16S4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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sodium 7,7'-(((ethene-1,2-diylbis(3-sulfonato-4,1-phenylene))bis(azanediyl))bis(carbonyl))bis(8-hydroxyquinoline-5-sulfonate)
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References
1. Verma R, et al. Science. 2004 Oct 1;306(5693):117-20.
2. Bellare P, et al. Nat Struct Mol Biol. 2008 May;15(5):444-51.
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