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Chemical Structure : UniPR129
Catalog No.: PC-20805Not For Human Use, Lab Use Only.
UniPR129 is a potent, selective Eph/ephrin antagonist, competitively disrupts Eph2A-ephrin-A1 binding (IC50=945 nM, Ki = 345 nM).
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UniPR129 is a potent, selective Eph/ephrin antagonist, competitively disrupts Eph2A-ephrin-A1 binding (IC50=945 nM, Ki = 345 nM).
UniPR129 blocks the interaction of ephrin-A1 and ephrin-B1 with all Eph receptors (IC50 = 840 nM - 1.54 µM for EphA and 2.6 - 3.74 µM for EphB).
UniPR129 inhibits EphA2 phosphorylation in PC3 prostate cancer cells (IC50 = 5 µM), does not affect tyrosine kinase activity of EGF and VEGF receptors.
UniPR129 inhibits angiogenesis in HUVEC (IC50 = 5.2 µM) and reduces ephrin-induced activation of EPhA2 and EphB4 (IC50 = 26.3 and 18.4 µM, respectively).
| M.Wt | 576.82 | |
| Formula | C36H52N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Giorgio C, et al. Biochem Pharmacol. 2018;147:21-29.
2. Hassan-Mohamed, I., et al. 2014. Brit. Journ. Pharm. 171, 5195.
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