Catalog No.: PC-26884Not For Human Use, Lab Use Only.
Ursocholic acid (UCA) is a natural bile acid with established cholesterol-lowering properties, is a direct AMPK agonist and promotes Thr172 phosphorylation, and downregulates lipogenic genes (SREBF1, LPIN1, FASN, SCD1).
Ursocholic acid (UCA) is a natural bile acid with established cholesterol-lowering properties, is a direct AMPK agonist and promotes Thr172 phosphorylation, and downregulates lipogenic genes (SREBF1, LPIN1, FASN, SCD1). Ursocholic acid dose-dependently reduced hepatic lipid accumulation in vitro and in vivo. Ursocholic acid ameliorates hepatic steatosis via direct AMPK activation in preclinical models of MASLD. Ursocholic acid shows activities of anti-apoptosis, anti-inflammatory, immunomodulatory, bile regulation, and coordinated changes in mitochondrial integrity and cell signaling.
