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Chemical Structure : Usmarapride
Catalog No.: PC-73299Not For Human Use, Lab Use Only.
Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist with EC50of 44 nM.
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Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist with EC50of 44 nM.
Usmarapride (SUVN-D4010) showed balanced physicochemical-pharmacokinetic properties with robust nonclinical efficacy in cognition models.
Usmarapride (SUVN-D4010) also showed disease-modifying potential, as it increased neuroprotective soluble amyloid precursor protein alpha levels, and dose-dependent target engagement and correlation of efficacy with oral exposures.
| M.Wt | 473.530 | |
| Formula | C23H31N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nirogi R, et al. J Med Chem. 2021 Aug 12;64(15):10641-10665.
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