VAP-1185 | Mast cell activator | Probechem Biochemicals

Chemical Structure : VAP-1185

VAP-1185 (VAP1185)

Catalog No.: PC-27346Not For Human Use, Lab Use Only.

VAP-1185 is a potent small molecule mast cell activator (MCA), induces mouse BMMCs degranulation, promotes a Th1-biased immune response when combined with TLR9 agonist CpG.

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Biological Activity

VAP-1185 is a potent small molecule mast cell activator (MCA), induces mouse BMMCs degranulation, promotes a Th1-biased immune response when combined with TLR9 agonist CpG.
VAP-1185 combined with CpG induces an inflammatory cytokine response in vitro.
VAP-1185 combined with CpG induces additive humoral effects in vivo.
VAP-1185 combined with CpG provides protection in a lethal challenge model.

Physicochemical Properties

M.Wt	364.42
Formula	C19H23F3N4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(4-isopropylphenyl)-2-(3-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine

References

1. Choi HW, et al. SLAS Discov. 2019 Jul;24(6):628-640.

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VAP-1185 (VAP1185)

Biological Activity

Physicochemical Properties

References

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