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Chemical Structure : VEGFR inhibitor F16
Catalog No.: PC-38754Not For Human Use, Lab Use Only.
F16 is a novel specific angiogenesis inhibitor, effectively reduces cell proliferation, tube formation, and migration of HUVECs in a concentration-dependent manner by directly inhibiting VEGF binding and subsequent VEGFR-2 phosphorylation.
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F16 is a novel specific angiogenesis inhibitor, effectively reduces cell proliferation, tube formation, and migration of HUVECs in a concentration-dependent manner by directly inhibiting VEGF binding and subsequent VEGFR-2 phosphorylation.
F16 is also able to inhibit the PI3K/PKB-mediated survival and migration pathways in cancer in addition to inhibiting the FAK and MAPKs-mediated signaling in GI-101A cancer cells.
F16 is a specific inhibitor of angiogenesis in both in vitro and in vivo models.
F16 also works very efficiently with Taxol in combination by limiting the tumor growth that is better than the monotherapy with any one of the drugs that were tested individually.
| M.Wt | 301.214 | |
| Formula | C13H7N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Appu Rathinavelu, et al. Tumour Biol. 2017 Nov;39(11):1010428317726841.
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