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Chemical Structure : VGTI-A3-03
Catalog No.: PC-35007Not For Human Use, Lab Use Only.
VGTI-A3-03 is a novel potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM), directly bind DENV capsid protein.
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VGTI-A3-03 is a novel potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM), directly bind DENV capsid protein; also demonstrates some inhibitory activity against DENV1, DENV4, and WNV; does not inhibit viral RNA replication or secretion of viral particles, significantly diminishe secreted particles in treated cells, the binding pocket in the capsid molecule is at the dimerization interface; VGTI-A3-03 is incorporated into virus particles released from infected cells.
| M.Wt | 483.608 | |
| Formula | C26H21N5OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Smith JL, et al. Antiviral Res. 2018 Apr 27;155:12-19.
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