Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : VIT-2763
CAS No.: 2095668-10-1
Catalog No.: PC-73101Not For Human Use, Lab Use Only.
VIT-2763 (Vamifeport, VIT2763) is an oral small molecule inhibitor of ferroportin, inhibits hepcidin binding to ferroportin with IC50 of 9 nM, blocks iron efflux.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $188 | In stock | |
| 5 mg | $288 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
VIT-2763 (Vamifeport, VIT2763) is an oral small molecule inhibitor of ferroportin, inhibits hepcidin binding to ferroportin with IC50 of 9 nM, blocks iron efflux.
VIT-2763 triggers ubiquitination and subsequent internalization and degradation of ferroportin.
Orally dosed VIT-2763 (30 mg/kg) decreased decrease in serum iron induced by hepcidin in rodents.
VIT-2763 decreased serum iron and prevented liver iron loading in Hbbth3/+ mice.
VIT-2763 significantly corrected anemia and improved RBC parameters in Hbbth3/+ mice, improved the ineffective erythropoiesis in BM and spleen.
VIT-2763 reduced the formation of insoluble α-globin aggregates and improved the elimination of mitochondria in RBCs.
VIT-2763 decreased apoptosis and extended the life span, reduced hypoxia response of RBCs.
| M.Wt | 408.437 | |
| Formula | C21H21FN6O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(2-((2-(1H-benzo[d]imidazol-2-yl)ethyl)amino)ethyl)-N-((3-fluoropyridin-2-yl)methyl)oxazole-4-carboxamide |
|
1. Manolova V, et al. J Clin Invest. 2019 Dec 9;130(1):491-506.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
