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Chemical Structure : VK-1727
Catalog No.: PC-36124Not For Human Use, Lab Use Only.
VK-1727 (VK1727) is a small-molecule inhibitor of the DNA binding activity of EBNA1 (Epstein-Barr nuclear antigen1).
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VK-1727 (VK1727) is a small-molecule inhibitor of the DNA binding activity of EBNA1 (Epstein-Barr nuclear antigen1).
VK-1727 selectively inhibits proliferation of EBV-positive cells (C666-1 CC50=6.3 uM) but not similarly growing EBV-negative cells.
VK-1727 potently inhibits EBNA1-dependent OriP DNA replicationm without effect on EBNA1 protein expression in EBV-positive NPC cell line, C666-1.
VK-1727 significantly blocks EBV-positive tumor growth in vivo (10 mg/kg, intraperitoneally, TGI=88.3%), block EBV gene transcription and alter the cellular TGF-β signaling pathway in NPC tumor xenografts.
| M.Wt | 451.522 | |
| Formula | C29H25NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Messick TE, et al. Sci Transl Med. 2019 Mar 6;11(482). pii: eaau5612. doi: 10.1126/scitranslmed.aau5612.
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