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Chemical Structure : VP15 hydrochloride
Catalog No.: PC-49073Not For Human Use, Lab Use Only.
VP15 hydrochloride (VP-15 HCl) is a BBB-penetrant, orally active, multitarget directed ligand against acetylcholine and monoamine oxidase enzymes with IC50 of 0.04 and 0.37 uM for AChE and MAO-B, respectively, >600-fold selectivity over BuChE.
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VP15 hydrochloride (VP-15 HCl) is a BBB-penetrant, orally active, multitarget directed ligand against acetylcholine and monoamine oxidase enzymes with IC50 of 0.04 and 0.37 uM for AChE and MAO-B, respectively, >600-fold selectivity over BuChE.
VP15 hydrochloride exhibited potent neuroprotective potential against 6-hydroxydopamine-induced neuronal damage in SH-SY5Y cells with up to 90% recovery.
VP15 hydrochloride significantly attenuated the spatial memory impairment and improved the cognitive deficits in the mice.
VP15 hydrochloride was an irreversible inhibitor and showed no cytotoxicity against neuronal cells.
| M.Wt | 464.010 | |
| Formula | C26H30ClN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bhupinder Kumar, et al. ACS Chem. Neurosci. 2022.
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