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Chemical Structure : VRX-0466617
Catalog No.: PC-60200Not For Human Use, Lab Use Only.
VRX-0466617 (VRX0466617) is a potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM.
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VRX-0466617 (VRX0466617) is a potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM.
VRX-0466617 shows no inhibitory effect on Chk1 (>100 uM).
VRX-0466617 inhibits the phosphorylation of Chk2 Ser(19) and Ser(33-35), but not of Chk2 Thr(68), prevents the IR-induced Chk2-dependent degradation of Hdmx and attenuates IR-induced apoptosis.
| M.Wt | 462.366 | |
| Formula | C19H20BrN5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carlessi L, et al. Mol Cancer Ther. 2007 Mar; 6(3):935-44.
2. Carlessi L, et al. Biochim Biophys Acta. 2010 Oct;1803(10):1213-23.
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