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Chemical Structure : VS-II-173
Catalog No.: PC-36029Not For Human Use, Lab Use Only.
VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell).
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VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell).
VS-II-173 acts synergistically with the anthracycline daunorubicin, and additively with a number of other anti-cancer drugs.
VS-II-173 attenuates phosphorylation of Pim kinase substrates, shows towards cell lines harboring the FLT3-ITD mutation (Molm-13, FLT3-ITD heterozygous and MV4-11 FLT3-ITD homozygous) with EC50 of 2-3 uM.
VS-II-173 also induces cell death also in AML patient blasts, including blast carrying high-risk FLT3-ITD mutation.
| M.Wt | 264.244 | |
| Formula | C14H8N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Suchaud V, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4704-10.
2. Bjørnstad R, et al. Mol Cancer Ther. 2019 Jan 24. pii: molcanther.1234.2017. doi: 10.1158/1535-7163.MCT-17-1234.
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