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Chemical Structure : VT107
CAS No.: 2417718-63-7
Catalog No.: PC-72507Not For Human Use, Lab Use Only.
VT107 (VT-107) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 4.93 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VT107 (VT-107) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 4.93 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor.
VT107 inhibited palmitoylation of both endogenous TEAD1, TEAD3, and TEAD4 proteins in cells.
VT107 decreased the levels of palmitoylated TEAD3 and TEAD4 and increased the levels of unpalmitoylated TEAD3 and TEAD4 in the human mesothelioma cell line NCI-H2373.
VT107 blocked YAP and TAZ interaction with both TEAD1 and TEAD4.
VT107 exhibited inhibitory activity in more mesothelioma cell lines than the TEAD1-selective inhibitor VT103.
| M.Wt | 435.45 | |
| Formula | C25H20F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1S)-1-(6-Amino-2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide |
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1. Tracy T Tang, et al. Mol Cancer Ther. 2021 Jun;20(6):986-998.
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