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VU590

Chemical Structure : VU590

CAS No.: 313505-85-0

VU590 (VU-590;VU 590)

Catalog No.: PC-60569Not For Human Use, Lab Use Only.

VU590 is the first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK.

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Biological Activity

VU590 is the first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK.
VU590 also inhibits inwardly rectifying K+ channel Kir7.1 (IC50=5.6 uM), but has no activity for Kir2.1 or Kir4.1.
VU590 induces profound, long-lasting contractions in mouse and human myometrium.

Physicochemical Properties

M.Wt 488.541
Formula C24H32N4O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane

References

1. Lewis LM, et al. Mol Pharmacol. 2009 Nov;76(5):1094-103.

2. Bhave G, et al. Mol Pharmacol. 2011 Jan;79(1):42-50.

3. McCloskey C, et al. EMBO Mol Med. 2014 Sep;6(9):1161-74.

4. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346.

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