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Chemical Structure : VU714 oxalate
Catalog No.: PC-60574Not For Human Use, Lab Use Only.
A potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays.
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A potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays; inhibits other Kir channels with a rank order potency of Kir4.1 (IC50=13 µM) > Kir1.1 (IC50=16 µM) > Kir6.2/SUR1 (IC50=30 µM) > Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 (IC50 > 30 µM).
| M.Wt | 456.92 | |
| Formula | C24H25ClN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346.
2. Swale DR, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23.
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