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Chemical Structure : VV116
CAS No.: 2647442-33-7
Catalog No.: PC-38735Not For Human Use, Lab Use Only.
VV116 (Mindeudesivir, JT001) is a promising orally active remdesivir derivative against SARS-CoV-2, targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with IC50 of 0.67 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $548 | In stock | |
| 100 mg | Get quote |
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VV116 (Mindeudesivir, JT001) is a promising orally active remdesivir derivative against SARS-CoV-2, targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with IC50 of 0.67 uM.
VV116 shows excellent efficacy in inhibiting SARS-CoV-2 replication in cell-based and animal models.
VV116 also is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model.
| M.Wt | 502.54 | |
| Formula | C24H30DN5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl-5-d)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate) |
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1. Xie Y, et al. Cell Res. 2021 Nov;31(11):1212-1214.
2. Wu CR, et al. Acta Pharmacol Sin. 2022 Jan 20:1-13.
3. Zhang R, et al. Signal Transduct Target Ther. 2022 Apr 16;7(1):123.
4. Shen Y, et al. Emerg Microbes Infect. 2022 May 17:1-22.
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