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Chemical Structure : VX-765
CAS No.: 273404-37-8
Catalog No.: PC-43391Not For Human Use, Lab Use Only.
VX-765 (Belnacasan) is an orally absorbed prodrug of VRT-043198, which is a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 with Ki of 0.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 25 mg | $148 | In stock | |
| 100 mg | $368 | In stock | |
| 500 mg | $688 | In stock |
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VX-765 (Belnacasan) is an orally absorbed prodrug of VRT-043198, which is a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 with Ki of 0.8 nM; VRT-043198 exhibits 100- to 10,000-fold selectivity against other caspase-3 and -6 to -9, VX-765 is converted rapidly to VRT-043198 under the action of plasma and liver esterases; inhibits LPS-induced IL-1β production, reduces disease severity and the expression of inflammatory mediators in models of rheumatoid arthritis and skin inflammation.
Epilepsy
Phase 2 Discontinued
| M.Wt | 508.995 | |
| Formula | C24H33ClN4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 27 mg/mL |
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| Chemical Name/SMILES |
L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]- |
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1. Stack JH, et al. J Immunol. 2005 Aug 15;175(4):2630-4.
2. Wannamaker W, et al. J Pharmacol Exp Ther. 2007 May;321(2):509-16.
3. Bialer M, et al. Epilepsy Res. 2013 Jan;103(1):2-30.
4. Wang W, et al. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9587-92.
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