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Chemical Structure : VY-3-135
CAS No.: 1824637-41-3
Catalog No.: PC-38179Not For Human Use, Lab Use Only.
VY-3-135 is a potent, specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, does not inhibits AcCoA synthetase family member ACSS1 and ACSS3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
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VY-3-135 is a potent, specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, does not inhibits AcCoA synthetase family member ACSS1 and ACSS3.
VY-3-135 completely blocked fatty acid synthesis from acetate in SKBr3 cells.
VY-3-135 inhibited mouse TNBC tumor growth in ACSS2high tumors but not ACSS2low tumors.
| M.Wt | 429.52 | |
| Formula | C26H27N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-1-Ethyl-2-(hydroxydiphenylmethyl)-N-(2-hydroxypropyl)-1H-benzo[d]imidazole-6-carboxamide |
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1. Miller KD, et al. Cancer Res. 2021 Mar 1;81(5):1252-1264.
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