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Chemical Structure : Vabicaserin
Catalog No.: PC-73309Not For Human Use, Lab Use Only.
Vabicaserin (SCA-136) is a potent, selective 5-HT2C receptor full agonist with EC50 of 8 nM, Emax 100%.
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Vabicaserin (SCA-136) is a potent, selective 5-HT2C receptor full agonist with EC50 of 8 nM, Emax 100%.
Vabicaserin displaced (125)I-(2,5-dimethoxy)phenylisopropylamine binding from human 5-HT(2C) receptor sites in CHO cell membranes with Ki of 3 nM, >50-fold selective over a number of serotonergic, noradrenergic, and dopaminergic receptors.
Vabicaserin is a potent and full agonist in stimulating 5-HT(2C) receptor-coupled calcium mobilization and exhibited 5-HT(2A) receptor antagonism and 5-HT(2B) antagonist or partial agonist activity in transfected cells, depending on the level of receptor expression.
| M.Wt | 264.797 | |
| Formula | C15H21ClN2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dunlop J, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):673-80.
2. Ogino S, et al. Pharmacol Biochem Behav. 2013 Jul;108:8-15.
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