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Valsartan

Chemical Structure : Valsartan

CAS No.: 137862-53-4

Valsartan (CGP-48933, CGP48933)

Catalog No.: PC-45431Not For Human Use, Lab Use Only.

Valsartan (CGP-48933) is a potent, selective angiotensin II type 1 receptor (AT1 receptor) antagonist with IC50 of 2.7 nM, >20,000-fold selective over AT2 receptor, shows potential for high blood pressure and heart failure.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Valsartan (CGP-48933) is a potent, selective angiotensin II type 1 receptor  (AT1 receptor) antagonist with IC50 of 2.7 nM, >20,000-fold selective over AT2 receptor, shows potential for high blood pressure and heart failure.

Physicochemical Properties

M.Wt 435.5188
Formula C24H29N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

References

1. Shan H, et al. J Cell Mol Med. 2014 Jun;18(6):1071-80.

2. Sui X, et al. J Cell Mol Med. 2015 Aug;19(8):1773-82.

3. Jiang Y, et al. Cardiovasc Pathol. 2015 Jul-Aug;24(4):224-9.

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