Catalog No.: PC-43400Not For Human Use, Lab Use Only.
Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM.
Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM.
Vanoxerine also is a potent hK(v)11.1 blocker, and at submicromolar concentrations.
Vanoxerine blocks Ca and Na currents in a strongly frequency-dependent manner possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but with cardiac ion channel effects.
Vanoxerine also is a cancer-specific downregulator of G9a expression, suppresses cancer stem cell functions in colon tumors.
