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Chemical Structure : Vercirnon
CAS No.: 698394-73-9
Catalog No.: PC-73249Not For Human Use, Lab Use Only.
Vercirnon (GSK1605786A, CCX282-B) is a potent, selective, orally bioavailable antagonist of CCR9, inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 of 5.4 and 3.4 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | $1180 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Vercirnon (GSK1605786A, CCX282-B) is a potent, selective, orally bioavailable antagonist of CCR9, inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 of 5.4 and 3.4 nM, respectively.
Vercirnon (GSK1605786A, CCX282-B) displays high selectivity for CCR9 over CCR1-12 and CX3CR1-7 (IC50>10 uM).
Vercirnon (GSK1605786A, CCX282-B) is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively.
CCX282-B also inhibited mouse and rat CCR9-mediated chemotaxis.
Inhibition of CCR9 with CCX282-B results in normalization of Crohn's disease such as histopathology associated with the TNF(ΔARE) mice.
| M.Wt | 444.93 | |
| Formula | C22H21ClN2O4S | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Walters MJ, et al. J Pharmacol Exp Ther. 2010 Oct;335(1):61-9.
2. Keshav S, et al. PLoS One. 2013;8(3):e60094.
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