Chemical Structure : Vinorelbine
Catalog No.: PC-42866Not For Human Use, Lab Use Only.
Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.
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Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.
Chemotherapeutic Agents
Approved
M.Wt | 778.9323 | |
Formula | C45H54N4O8 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Rahmani R, et al. Cancer Chemother Pharmacol. 1986;16(3):223-8.
2. Ngan VK, et al. Mol Pharmacol. 2001 Jul;60(1):225-32.
3. Monnet I, et al. Eur J Cancer. 1991;27(12):1716-7.
4. Rahmani R, et al. Cancer Res. 1984 Dec;44(12 Pt 1):5609-13.
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