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Vinorelbine

Chemical Structure : Vinorelbine

CAS No.: 71486-22-1

Vinorelbine (KW-2307)

Catalog No.: PC-42866Not For Human Use, Lab Use Only.

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.

Chemotherapeutic Agents

Approved

Physicochemical Properties

M.Wt 778.9323
Formula C45H54N4O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-

References

1. Rahmani R, et al. Cancer Chemother Pharmacol. 1986;16(3):223-8.

2. Ngan VK, et al. Mol Pharmacol. 2001 Jul;60(1):225-32.

3. Monnet I, et al. Eur J Cancer. 1991;27(12):1716-7.

4. Rahmani R, et al. Cancer Res. 1984 Dec;44(12 Pt 1):5609-13.

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