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Chemical Structure : Vinorelbine ditartrate
CAS No.: 125317-39-7
Catalog No.: PC-42867Not For Human Use, Lab Use Only.
Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $58 | In stock | |
| 50 mg | $158 | In stock | |
| 250 mg | $268 | In stock | |
| 1 g | Get quote |
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Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.
Chemotherapeutic Agents
Approved
| M.Wt | 1079.106 | |
| Formula | C53H66N4O20 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dih |
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1. Rahmani R, et al. Cancer Chemother Pharmacol. 1986;16(3):223-8.
2. Ngan VK, et al. Mol Pharmacol. 2001 Jul;60(1):225-32.
3. Monnet I, et al. Eur J Cancer. 1991;27(12):1716-7.
4. Rahmani R, et al. Cancer Res. 1984 Dec;44(12 Pt 1):5609-13.
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