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Chemical Structure : Vismodegib
CAS No.: 879085-55-9
Catalog No.: PC-42586Not For Human Use, Lab Use Only.
Vismodegib (GDC-0449) is a potent, selective, orally bioavailable smoothened (Smo) inhibitor, blocks Shh signaling with EC50 of 40 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $118 | In stock | |
| 50 mg | $178 | In stock | |
| 100 mg | $278 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Vismodegib (GDC-0449) is a potent, selective, orally bioavailable smoothened (Smo) inhibitor, blocks Shh signaling with EC50 of 40 nM.
Vismodegib (GDC-0449) inhibits proliferation, increases apoptosis, and alters morphology, suppresses the Shh pathway in mouse medulloblastoma in vivo.
Vismodegib (GDC-0449) also is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp.
Vismodegib (GDC-0449) is the first Hedgehog signaling pathway targeting agent to gain FDA approval.
| M.Wt | 421.2971 | |
| Formula | C19H14Cl2N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)- |
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1. Romer JT, et al. Cancer Cell. 2004 Sep;6(3):229-40.
2. Robarge KD, et al. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5576-81.
3. Dijkgraaf GJ, et al. Cancer Res. 2011 Jan 15;71(2):435-44.
4. Yauch RL, et al. Science. 2009 Oct 23;326(5952):572-4.
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