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Vonafexor

Chemical Structure : Vonafexor

CAS No.: 1192171-69-9

Vonafexor (EYP001, EYP-001)

Catalog No.: PC-28796Not For Human Use, Lab Use Only.

Vonafexor (EYP001) is a synthetic, orally active, non-steroidal, non-bile acid agonist of arnesoid X receptor (FXR), also inhibits HBV transcriptional activity, blocks c-Rel nuclear entry in MDSCs, induces sublethal damage of HBV-positive liver cancer cells.

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Biological Activity

Vonafexor (EYP001) is a synthetic, orally active, non-steroidal, non-bile acid agonist of farnesoid X receptor (FXR), also inhibits HBV transcriptional activity, blocks c-Rel nuclear entry in MDSCs, induces sublethal damage of HBV-positive liver cancer cells.

Physicochemical Properties

M.Wt 489.75
Formula C19H15Cl3N2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Chloro-5-(4-((2,6-dichlorophenyl)sulfonyl)piperazin-1-yl)benzofuran-2-carboxylic acid

References

1. Ratziu V, et al. J Hepatol. 2023 Mar;78(3):479-492.

2. Pan B, et al. Br J Cancer. 2025 Sep;133(5):697-708.

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