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Chemical Structure : Voreloxin
CAS No.: 175414-77-4
Catalog No.: PC-42643Not For Human Use, Lab Use Only.
Voreloxin (SNS-595;Vosaroxin;AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.
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|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Voreloxin (SNS-595; Vosaroxin; AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.
| M.Wt | 401.4396 | |
| Formula | C18H19N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)- |
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1. Scatena CD, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8.
2. Hoch U, et al. Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65.
3. Walsby EJ, et al. Haematologica. 2011 Mar;96(3):393-9.
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