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Chemical Structure : Voxtalisib
CAS No.: 934493-76-2
Catalog No.: PC-44791Not For Human Use, Lab Use Only.
Voxtalisib (XL765, SAR245409) is a potent, highly selective ATP-competitive inhibitor of class I PI3Ks with IC50s of 39/110/43/9 nM for p110α/p110β/p110δ/p120γ.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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Voxtalisib (XL765, SAR245409) is a potent, highly selective ATP-competitive inhibitor of class I PI3Ks with IC50s of 39/110/43/9 nM for p110α/p110β/p110δ/p120γ.
Voxtalisib (XL765, SAR245409) also inhibits mTORC1/mTORC2/DNA-PK (IC50=160/910/150 nM) and shows weak inhibitory activity toward VPS34 (IC50=9.1 uM).
Voxtalisib (XL765, SAR245409) inhibits phosphorylation of AKT, p70S6K, and S6 phosphorylation in multiple tumor cell lines.
Voxtalisib (XL765, SAR245409) is orally bioactive in mouse xenograft models.
| M.Wt | 270.2899 | |
| Formula | C13H14N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 16 mg/mL |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)- |
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1. Yu P, et al. Mol Cancer Ther. 2014 May;13(5):1078-91.
2. Papadopoulos KP, et al. Clin Cancer Res. 2014 May 1;20(9):2445-56.
3. Thijssen R, et al. Leukemia. 2016 Feb;30(2):337-45.
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