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Chemical Structure : W-212393
Catalog No.: PC-61541Not For Human Use, Lab Use Only.
W-212393 (MT-7716 free base) is a highly potent, brain penetrant ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively.
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W-212393 (MT-7716 free base) is a highly potent, brain penetrant ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively.
W-212393 displays a relative selectivity over μ receptor and serotonin transporter.
W-212393 significantly suppresses the activity of spontaneously firing rat suprachiasmatic nucleus neurons at 100 nM.
W-212393 induces a significant phase advance at circadian time 6 (CT6) and CT9, but not at other CTs, represents an interesting agent for the study of circadian rhythms.
MT-7716 dose-dependently decreases GABAergic transmission and effectively blocks the ethanol-induced increase in GABA release at these synapses.
| M.Wt | 440.547 | |
| Formula | C27H28N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Teshima K, et al. Br J Pharmacol. 2005 Sep;146(1):33-40.
2. Miyakawa K, et al. Neuropharmacology. 2007 Mar;52(3):1055-64.
3. Kallupi M, et al. Front Integr Neurosci. 2014 Feb 18;8:18.
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