Chemical Structure W-212393
CAS No.: 610323-32-5
Catalog No.: PC-61541Not For Human Use, Lab Use Only.
W-212393 (MT-7716 free base) is a highly potent, brain penetrant ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively.
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W-212393 (MT-7716 free base) is a highly potent, brain penetrant ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively; displays a relative selectivity over μ receptor and serotonin transporter; significantly suppresses the activity of spontaneously firing rat suprachiasmatic nucleus neurons at 100 nM; induces a significant phase advance at circadian time 6 (CT6) and CT9, but not at other CTs, represents an interesting agent for the study of circadian rhythms; MT-7716 dose-dependently decreases GABAergic transmission and effectively blocks the ethanol-induced increase in GABA release at these synapses.
Phase 1 Discontinued