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Chemical Structure : WAY 163909
Catalog No.: PC-61117Not For Human Use, Lab Use Only.
A highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM, >20-fold selectivity over 5-HT2A and 5-HT2B receptor subtypes (IC50=212 and 485 nM, respectively).
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A highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM, >20-fold selectivity over 5-HT2A and 5-HT2B receptor subtypes (IC50=212 and 485 nM, respectively); stimulates the mobilization of intracellular calcium in CHO cells stably expressing the human 5-HT2C with EC50 of 8 nM; produces a dose-dependent reduction in food intake in rat (ED50=2.93 mg/kg), also exhibits preclinical antipsychotic-like activity in vivo.
| M.Wt | 214.31 | |
| Formula | C14H18N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dunlop J, et al. J Pharmacol Exp Ther. 2005 May;313(2):862-9.
2. Marquis KL, et al. J Pharmacol Exp Ther. 2007 Jan;320(1):486-96.
3. Rosenzweig-Lipson S, et al. Psychopharmacology (Berl). 2007 Jun;192(2):159-70.
4. Grauer SM, et al. Psychopharmacology (Berl). 2009 May;204(1):37-48.
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