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WEE1-CK1α molecular glue degrader 1

Chemical Structure : WEE1-CK1α molecular glue degrader 1

CAS No.:

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WEE1-CK1α molecular glue degrader 1

Catalog No.: PC-23399Not For Human Use, Lab Use Only.

WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively.
WEE1-CK1α molecular glue degrader 1 has a significant antiproliferative effect (EC50 = 12 nM, MOLT-4 cells).

Physicochemical Properties

M.Wt 431.50
Formula C24H25N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(5-(3-(tert-butylamino)imidazo[1,2-a]pyridin-2-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Razumkov H, et al. J Am Chem Soc. 2024 Nov 5. doi: 10.1021/jacs.4c06127.

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