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WR99210

Chemical Structure : WR99210

CAS No.: 47326-86-3

WR99210 (WR 99210)

Catalog No.: PC-20655Not For Human Use, Lab Use Only.

WR99210 is an effective inhibitor of dihydrofolate reductase (DHFR) with IC50 of <0.075 nM, shows activity agianst pyrimethamine-resistant P. falciparum strains.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WR99210 is an effective inhibitor of dihydrofolate reductase (DHFR) with IC50 of <0.075 nM, shows activity agianst pyrimethamine-resistant P. falciparum strains.

Physicochemical Properties

M.Wt 394.68
Formula C14H18Cl3N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,6-Dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine

References

1. Hastings MD, et al. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.

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