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WW-104

Chemical Structure : WW-104

CAS No.: 3124394-45-9

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WW-104 (WW104)

Catalog No.: PC-25948Not For Human Use, Lab Use Only.

WW-104 is a specific small molecule USP10 inhibitor with IC50 of 16.75 uM and strong binding affinity with SPR Kd of 237 nM, shows no detectable inhibitory activity against USP7.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WW-104 is a specific small molecule USP10 inhibitor with IC50 of 16.75 uM and strong binding affinity with SPR Kd of 237 nM, shows no detectable inhibitory activity against USP7.
    WW-104 demonstrates potent antiproliferative activity with IC50 of 2.8 uM in Huh-7 cell line.
    WW-104 exhibits slightly weaker antiproliferative activity in USP10-overexpressing Huh-6 cell line (IC50=6.29 uM).
    WW-104 (5-20 uM) induces the G2 phase arrest and cell apoptosis in Huh-7 cell lines.

    Physicochemical Properties

    M.Wt 515.99
    Formula C29H26ClN3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-chlorophenethyl)-2-(2-(3,4-dihydro-2H-benzo[b][1,4]oxazine-4‑carbonyl)-7-methyl-4-oxoquinolin-1(4H)-yl)acetamide

    References

    1. Wang W, et al. Bioorg Chem. 2025 Dec 15;169:109348.

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