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Chemical Structure : WWL113
Catalog No.: PC-62253Not For Human Use, Lab Use Only.
WWL113 is a potent inhibitor of Carboxylesterase Ces3 and Ces1f by competitive ABPP of enzymes recombinantly expressed in HEK293T cells (IC50 value of 0.1 uM for each enzyme).
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WWL113 is a potent inhibitor of Carboxylesterase Ces3 and Ces1f by competitive ABPP of enzymes recombinantly expressed in HEK293T cells (IC50 value of 0.1 uM for each enzyme); doses not inhibit any of the other serine hydrolases; reduces the activity signals for ABHD6, promotes lipid storage in cultured adipocytes and prevents basal lipolysis; ameliorates obesity-diabetes in mice.
| M.Wt | 466.537 | |
| Formula | C29H26N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dominguez E, et al. Nat Chem Biol. 2014 Feb;10(2):113-21.
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