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Chemical Structure : WZ-3146
CAS No.: 1214265-56-1
Catalog No.: PC-42819Not For Human Use, Lab Use Only.
WZ-3146 is a potent, mutant-selective EGFR kinase inhibitor with IC50 of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746-A750, EGFRE746-A750/T790M and wt EGFR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $28 | In stock | |
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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WZ-3146 is a potent, mutant-selective EGFR kinase inhibitor with IC50 of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746-A750, EGFRE746-A750/T790M and wt EGFR, respectively.
WZ-3146 suppresses the growth of EGFR T790M containing cell lines and inhibit EGFR phosphorylation.
| M.Wt | 464.9473 | |
| Formula | C24H25ClN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]- |
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1. Zhou W, et al. Nature. 2009 Dec 24;462(7276):1070-4.
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