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Chemical Structure : WZ8040
CAS No.: 1214265-57-2
Catalog No.: PC-42843Not For Human Use, Lab Use Only.
WZ8040 is a potent, mutant-selective, irreversible EGFR T790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I) and is 100-fold less potent against wild-type EGFR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
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| 100 mg | Get quote |
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WZ8040 is a potent, mutant-selective, irreversible EGFR T790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I) and is 100-fold less potent against wild-type EGFR.
WZ8040 potently inhibits the growth of HCC827 (EGFR Del E746_A750), PC9 (EGFR Del E746_A750), H3255 (EGFR L858R), H1975 (EGFR L858R/T790M), and PC9 GR (EGFR Del E746_A750/T790M) with IC50 of 1 nM, 6 nM, 66 nM, 9 nM, and 8 nM, respectively.
| M.Wt | 481.0129 | |
| Formula | C24H25ClN6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Propenamide, N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]- |
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1. Zhou W, et al. Nature. 2009 Dec 24;462(7276):1070-4.
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