Catalog No.: PC-20897Not For Human Use, Lab Use Only.
Wedelolactone is a small molecule inhibitor of LPS-induced caspase-11 expression by directly inhibits the IKK Complex, also inhibits 5-lipoxygenase with IC50 of 2.5 uM.
Wedelolactone is a small molecule inhibitor of LPS-induced caspase-11 expression by directly inhibits the IKK Complex, also inhibits 5-lipoxygenase with IC50 of 2.5 uM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. enhances bone marrow mesenchymal stem cells (BMSC) differentiation towards osteoblasts. Wedelolactone inhibits GSK3β activity and increases β-catenin and runx2 nuclear accumulation in BMSC, and inhibits the effect of RANKL. Wedelolactone decreases bone volumn and trabecular number at the femur after ovarietomy, and prevents the VOX-induced bone loss.
