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Chemical Structure : Wedelolactone
CAS No.: 524-12-9
Catalog No.: PC-20897Not For Human Use, Lab Use Only.
Wedelolactone is a small molecule inhibitor of LPS-induced caspase-11 expression by directly inhibits the IKK Complex, also inhibits 5-lipoxygenase with IC50 of 2.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 1 g | Get quote |
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Wedelolactone is a small molecule inhibitor of LPS-induced caspase-11 expression by directly inhibits the IKK Complex, also inhibits 5-lipoxygenase with IC50 of 2.5 uM.
Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. enhances bone marrow mesenchymal stem cells (BMSC) differentiation towards osteoblasts.
Wedelolactone inhibits GSK3β activity and increases β-catenin and runx2 nuclear accumulation in BMSC, and inhibits the effect of RANKL.
Wedelolactone decreases bone volumn and trabecular number at the femur after ovarietomy, and prevents the VOX-induced bone loss.
| M.Wt | 314.25 | |
| Formula | C16H10O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,8,9-trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one |
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1. Kobori M, et al. Cell Death Differ. 2004 Jan;11(1):123-30.
2. Liu YQ, et al. Sci Rep. 2016 Aug 25;6:32260.
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