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Chemical Structure : X5050
Catalog No.: PC-72525Not For Human Use, Lab Use Only.
X5050 (X-5050) is a small molecule that inhibits REST silencing in a RE1-dependent manner, targeted REST degradation.
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X5050 (X-5050) is a small molecule that inhibits REST silencing in a RE1-dependent manner, targeted REST degradation.
X5050 reduce REST protein levels in cells at a concentration of the 50-100 μM, leading to a 50% REST reduction.
X5050 upregulated neuronal genes targeted by REST in wild-type neural cells, as well as in human induced pluripotent stem cells derived from a Huntington disease (HD) patient.
X5050 increased the expressions of BDNF and several other REST-regulated genes in the prefrontal cortex of mice with quinolinate-induced striatal lesions.
| M.Wt | 309.325 | |
| Formula | C17H15N3O3 | |
| Appearance | Solid | |
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1. Charbord J, et al. Stem Cells. 2013 Sep;31(9):1816-28.
2. Brenda Medellin, et al. J Med Chem. 2022 Jan 13;65(1):507-519.
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