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Chemical Structure : XAF-1407
Catalog No.: PC-72116Not For Human Use, Lab Use Only.
XAF-1407 (XAF1407) is a novel putatively potent and highly specific IK,Ach (Kir3.1/3.4 and Kir3.4/3.4) inhibitor (IC50 of 1.1 and 3.2 nM, respectively).
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XAF-1407 (XAF1407) is a novel putatively potent and highly specific IK,Ach (Kir3.1/3.4 and Kir3.4/3.4) inhibitor (IC50 of 1.1 and 3.2 nM, respectively).
XAF-1407 displays highly selectivity other relevant cardiac ion channels, with selectivity ratios for Kir3.1/3.4 of >2,000–8,000 fold up to >27,000 fold for Nav1.5 and Kir2.1, respectively.
XAF-1407 potently and selectively inhibited Kir 3.1/3.4 and Kir 3.4/3.4, underlying the IK,ACh current.
XAF-1407 treatment in horses prolonged atrial effective refractory period as well as decreased atrial fibrillatory rate significantly and successfully cardioverted atrial fibrillation (AF), although with a decreasing efficacy over time. XAF-1407 shortened atrioventricular-nodal refractoriness, without effect on QRS duration.
| M.Wt | 507.697 | |
| Formula | C28H37N5O2S | |
| Appearance | Solid | |
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1. Fenner MF, et al. Br J Pharmacol. 2020 Aug;177(16):3778-3794.
2. Sobota V, et al. Front Pharmacol. 2021 Jan 27;11:608410.
3. Petersen J, et al. J Cardiovasc Pharmacol. 2022 Feb 14.
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