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Chemical Structure : XE991
CAS No.: 122955-42-4
Catalog No.: PC-63066Not For Human Use, Lab Use Only.
XE991 is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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XE991 is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
XE991 displays 14-fold less potency for KCNQ1+minK current with Kd of 11 uM.
XE991 enhances hippocampal ACh release from rat brain slices (EC50=490 nM) and is a cognitive enhancer in vivo.
| M.Wt | 376.45 | |
| Formula | C26H20N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone |
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1. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
2. Wang HS, et al. Mol Pharmacol. 2000 Jun;57(6):1218-23.
3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct;60(4):753-60.
4. Yeung SY, et al. Br J Pharmacol. 2005 Oct;146(4):585-95.
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