Chemical Structure : XL20
CAS No.:
2060801-74-1
XL20
Catalog No.: PC-27270Not For Human Use, Lab Use Only.
XL20 is a brain-penetrant small molecule targeting the TDP-43 conserved α-helical region spanning residues 320-340 (conserved region, CR) to suppress neurotoxicity, binds to full-length TDP-43 and CR peptide with SPR KD of 10.4 uM and 7.84 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
XL20 is a brain-penetrant small molecule targeting the TDP-43 conserved α-helical region spanning residues 320-340 (conserved region, CR) to suppress neurotoxicity, binds to full-length TDP-43 and CR peptide with SPR KD of 10.4 uM and 7.84 uM.
XL20 does not affect TDP-43 splicing activity.
XL20 demonstrates strong neuroprotection at concentrations as low as 6.25 µM in primary cortical neurons overexpressing TDP-43.
XL20 significantly increases the thermal stability of WT TDP-43 in cell lysates.
XL20 selectively suppresses CR-dependent TDP-43 assembly behaviors including LLPS and aggregation, and confers potent neuroprotection at low micromolar concentrations.
XL20 exhibits good CNS penetration.
XL20 attenuates TDP-43 neurotoxicity in mice and human motor neurons, slows disease progression in mutant TDP-43 transgenic mice.
Physicochemical Properties
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M.Wt
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352.44
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Formula
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C19H24N6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Cyclohexanol, 2-(6-amino-9H-purin-9-yl)-6-[methyl(phenylmethyl)amino]-, (1R,2R,6R)-rel-
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References
1. Gao J, et al. Nat Aging. 2026 Jul 3. doi: 10.1038/s43587-026-01166-3.
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