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Chemical Structure : XPC-5462
Catalog No.: PC-21779Not For Human Use, Lab Use Only.
XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively.
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XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively.
XPC-5462 displays weak activity against NaV1.7, and no significant effect on other NaV subtypes.
XPC-7224 (150 nM) significantly inhibits AP firing from pyramidal cells but not fast spiking interneurons. XPC-7224 inhibits neocortical ex vivo seizure-like events.
| M.Wt | 486.50 | |
| Formula | C20H18F4N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Samuel J Goodchild, et al. ACS Chem Neurosci. 2024 Feb 15.
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